Diazepam-induced hyperphagia after repeated-intravenous adminis-tration in rats
نویسندگان
چکیده
منابع مشابه
CHANGES IN BIOCHEMICAL PARAMETERS OF CARBOHYDRATE METABOLISM FOLLOWING FENFLURAMINE ADMINIS TRATION IN RATS
Fenfluramine, an anorexigenic agent, is widely used in the treatment of obesity. Besides its anorectic effect, it may also have some effects on general metabolism with the consequence of weight loss. In this study, the effect of fenfluramine on the concentrations of some parameters related to carbohydrate metabolism was investigated. It was shown that the serum insulin level was reduced by ...
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The present trial examined the possibility that diazepam (DZP, 1 mg/kg) induces hyperphagia by acting on the dopaminergic system. Quinpirole (QP), dopamine D-2 receptor agonist, was used for this purpose. Mice fasted for 24 hr were treated with QP 1 (QP-1) or 2 (QP-2) mg/kg 30 min prior to termination of the starvation. DZP was given to untreated mice and half of the QP-1 and QP-2 treated mice ...
متن کاملchanges in biochemical parameters of carbohydrate metabolism following fenfluramine adminis tration in rats
fenfluramine, an anorexigenic agent, is widely used in the treatment of obesity. besides its anorectic effect, it may also have some effects on general metabolism with the consequence of weight loss. in this study, the effect of fenfluramine on the concentrations of some parameters related to carbohydrate metabolism was investigated. it was shown that the serum insulin level was reduced by 41 %...
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15 صفحه اولIntravenous administration of diazepam in patients
was 17-9 + 1-4 mg (M ± SEM) compared with 27 ± 5-4 mg in controls (p < 0 01). Dose correlated significantly with serum albumin (p < 0-05). Baseline mean dominant frequency (MDF) and slow wave index (SWI) significantly correlated with albumin (p < 0 01). After diazepam, the MDF decreased and SWI increased. The change was greatest at the time of maximal clinical response. It was greater in liver ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58459-1